Ketones and Autism

Ketones and Cognitive Supporton June 16, 2017Leave a Comment

Yes there is a lot of growing interest in researching using ketosis to help improve symptoms of Autism, and several studies have been published on the topic over the past few years.

Here is a link to a downloadable PDF for a review paper on the topic:

Summary: Mice treated with the ketogenic diet had improvements in aspects of social behavior, including increased scores in sociability index and social novelty index (another way of measuring social behaviors in animal models).

Abstract: Nutr Neurosci. 2016 Feb 9. [Epub ahead of print]

The effect of ketogenic diet in an animal model of autism induced by prenatal exposure to valproic acid.

Castro KBaronio DPerry ISRiesgo RDGottfried C.

Summary: Autistic mice treated with the ketogenic diet showed improvements in multiple tests of sociability and behavior, including increased sociability, decreased self-directed repetitive behavior, and increased social communication.

PLoS One. 2013 Jun 5;8(6):e65021. doi: 10.1371/journal.pone.0065021. Print 2013.

Ketogenic diet improves core symptoms of autism in BTBR mice.

Summary: In this study, autistic mice treated with a ketogenic diet behaved more like healthy mice than those fed a standard higher carbohydrate diet. This included improvements in social and self-grooming behaviors, as well as a more normal pattern of neuronal activity in different brain regions.

Summary: It is thought that autism is caused in part by an increase of excitatory signaling in the brain. This study showed that the ketogenic diet reversed this abnormality in a mouse model of autism.

Abstract: Behav Brain Res. 2016 May 1;304:67-70. doi: 10.1016/j.bbr.2016.02.015. Epub 2016 Feb 11.

Ketogenic diet restores aberrant cortical motor maps and excitation-to-inhibition imbalance in the BTBR mouse model of autism spectrum disorder.

Smith J1Rho JM1Teskey GC2.

Cancer and Ketones

Ketones & KetoOSon June 16, 2017Leave a Comment

Cancer, ketones interview:
http://denversdietdoctor.com/ancestral-ketogenic-diets-and-brain-cancer-the-scarborough-protocol/

Clinical Data on Pain/Inflammation and Ketones:

Inflammationon June 16, 2017Leave a Comment

Clinical Data on Pain/Inflammation and ketones:

Of course this is the seminal paper demonstrating that the primary ketone body beta-hydroxybutyrate directly inhibits assembly of the NLRP3 inflammasome, thereby reducing inflammation.

Link: https://www.ncbi.nlm.nih.gov/pubmed/25686106

Nat Med. 2015 Mar;21(3):263-9. doi: 10.1038/nm.3804. Epub 2015 Feb 16.

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.

This paper describes how NLRP3 inflammasome activation plays a pivotal role in chronic pain.

Link: https://www.ncbi.nlm.nih.gov/pubmed/26132721

Antioxid Redox Signal. 2016 Jan 20;24(3):157-70. doi: 10.1089/ars.2014.6120. Epub 2015 Sep 16.

AMPK Phosphorylation Modulates Pain by Activation of NLRP3 Inflammasome.

Cognitive Improvements

Ketones and Cognitive Supporton June 16, 2017Leave a Comment

Neuroprotection For The Brain

Ketones and Cognitive Supporton June 16, 2017Leave a Comment

Improving Insulin Insensitivity

Ketogenic Diet and Blood Sugar/Insulin Sensitivityon June 16, 2017Leave a Comment

Carbs and Anxiety: Is there a relationship?

Ketones and ADHD/ADD/Anxietyon June 16, 2017Leave a Comment

I’ve read through all the questions here do to with alleviating anxiety, and have seen upping carb intake suggested a few times. But I’d like to understand this strategy better before I try it.

My quick history: I’ve been basically paleo for years, and recent bout of insomnia pushed me to try out a VLC diet and strive for ketosis, yet my anxiety seems to be getting worse. Of course it’s hard to tell if my stress is related to diet or just the general stress of the world (Fukushima is admittedly freaking me out, and since tumors generally don’t feed on ketones, the VLC/fat burning strategy appeals to me.)

I have been testing blood sugar with a glucometer lately, and VLC seems to have generally brought my blood sugar down. But I’ve discovered that when I feel panicky (which happens especially in the morning) my blood sugar will be high no matter what I eat, even after fasting for ten hours….The cortisol is pumping my blood sugar up! (And the belly fat remains.) So unless I get my anxiety under control, it seems that I won’t ever reach ketosis or lose the baby weight I’ve gained.

https://www.paleohacks.com/ketosis/carbs-and-anxiety-is-there-a-relationship-30347

 

Your Brain on Ketones…..

Ketones and ADHD/ADD/Anxietyon June 16, 2017Leave a Comment

How a High Fat Diet Can help the Brain Work Better:

The modern prescription of high carbohydrate, low fat diets and eating snacks between meals has coincided with an increase in obesity, diabetes, and and increase in the incidence of many mental health disorders, including depression, anxiety, and eating disorders. In addition, many of these disorders are striking the population at younger ages.

https://www.psychologytoday.com/blog/evolutionary-psychiatry/201104/your-brain-ketones

………… And what does it mean to have a ketogenic brain? Let’s examine neurotransmitters and brain energy more closely. Specifically, glutamate and GABA (5).

GABA is the major inhibitory neurotransmitter in the mammalian nervous system. Turns out, GABA is made from glutamate, which just happens to be the major excitatory neurotransmitter. You need them both, but we seem to get into trouble when have too much glutamate. Too much excitement in the brain means neurotoxicity, the extreme manifestation of which is seizures. But neurological diseases as varied as depression, bipolar disorder, migraines, ALS, and dementia have all been linked in some way to neurotoxicity.

Glutamate has several fates, rather like our old buddy tryptophan. It can become GABA (inhibitory), or aspartate (excitatory and, in excess, neurotoxic). Ketogenic diets seem to favor glutamate becoming GABA rather than aspartate. No one knows exactly why, but part of the reason has to do with how ketones are metabolized, and how ketosis favors using acetate (acetoacetate is one of the ketone bodies, after all) for fuel. Acetate becomes glutamine, an essential precursor for GABA…….

Effects of a ketogenic diet on ADHD-like behavior

Ketones and ADHD/ADD/Anxietyon June 16, 2017Leave a Comment

http://www.ncbi.nlm.nih.gov/pubmed/26773515

Epilepsy Behav. 2016 Feb;55:62-8. doi: 10.1016/j.yebeh.2015.11.014. Epub 2016 Jan 7.

Effects of a ketogenic diet on ADHD-like behavior in dogs with idiopathic epilepsy.

Packer RM1Law TH2Davies E3Zanghi B4Pan Y4Volk HA3.

Author information

OBJECTIVES:

Epilepsy in humans and rodent models of epilepsy can be associated with behavioral comorbidities including an increased prevalence of attention-deficit/hyperactivity disorder (ADHD). Attention-deficit/hyperactivity disorder symptoms and seizure frequency have been successfully reduced in humans and rodents using a ketogenic diet (KD). The aims of this study were (i) to describe the behavioral profile of dogs with idiopathic epilepsy (IE) while on a standardized nonketogenic placebo diet, to determine whether ADHD-like behaviors are present, and (ii) to examine the effect of a ketogenic medium chain triglyceride diet (MCTD) on the behavioral profile of dogs with idiopathic epilepsy (IE) compared with the standardized placebo control diet, including ADHD-like behaviors.

Ketones and Athletic Performance

Ketones and Physical Performanceon June 16, 2017Leave a Comment

No Impaired Endurance Performance When In Ketosis

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