Ketones and Autism

Yes there is a lot of growing interest in researching using ketosis to help improve symptoms of Autism, and several studies have been published on the topic over the past few years.

Here is a link to a downloadable PDF for a review paper on the topic:

Summary: Mice treated with the ketogenic diet had improvements in aspects of social behavior, including increased scores in sociability index and social novelty index (another way of measuring social behaviors in animal models).

Abstract: Nutr Neurosci. 2016 Feb 9. [Epub ahead of print]

The effect of ketogenic diet in an animal model of autism induced by prenatal exposure to valproic acid.

Castro KBaronio DPerry ISRiesgo RDGottfried C.

Summary: Autistic mice treated with the ketogenic diet showed improvements in multiple tests of sociability and behavior, including increased sociability, decreased self-directed repetitive behavior, and increased social communication.

PLoS One. 2013 Jun 5;8(6):e65021. doi: 10.1371/journal.pone.0065021. Print 2013.

Ketogenic diet improves core symptoms of autism in BTBR mice.

Summary: In this study, autistic mice treated with a ketogenic diet behaved more like healthy mice than those fed a standard higher carbohydrate diet. This included improvements in social and self-grooming behaviors, as well as a more normal pattern of neuronal activity in different brain regions.

Summary: It is thought that autism is caused in part by an increase of excitatory signaling in the brain. This study showed that the ketogenic diet reversed this abnormality in a mouse model of autism.

Abstract: Behav Brain Res. 2016 May 1;304:67-70. doi: 10.1016/j.bbr.2016.02.015. Epub 2016 Feb 11.

Ketogenic diet restores aberrant cortical motor maps and excitation-to-inhibition imbalance in the BTBR mouse model of autism spectrum disorder.

Smith J1Rho JM1Teskey GC2.

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