Clinical Data on Pain/Inflammation and Ketones:
Clinical Data on Pain/Inflammation and ketones:
Of course this is the seminal paper demonstrating that the primary ketone body beta-hydroxybutyrate directly inhibits assembly of the NLRP3 inflammasome, thereby reducing inflammation.
Link: https://www.ncbi.nlm.nih.gov/pubmed/25686106
Nat Med. 2015 Mar;21(3):263-9. doi: 10.1038/nm.3804. Epub 2015 Feb 16.
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.
This paper describes how NLRP3 inflammasome activation plays a pivotal role in chronic pain.
Link: https://www.ncbi.nlm.nih.gov/pubmed/26132721
Antioxid Redox Signal. 2016 Jan 20;24(3):157-70. doi: 10.1089/ars.2014.6120. Epub 2015 Sep 16.
AMPK Phosphorylation Modulates Pain by Activation of NLRP3 Inflammasome.
I have been practicing alongside my husband, Dr. Ralph S. Cardin, for the past 12 years and have worked in the health care environment for over 29 years. Besides being a passionate practitioner, I am a proud mother of four beautiful boys. I am active in my church and my children’s school and enjoy cooking and exercising.
